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Houston J., Vissotsky C., Deep A., Hakozaki H., Crews E., Oegema K., Corbett K.D., Lara-Gonzalez P., Kim T., Desai A. (2024) Phospho-KNL-1 recognition by a TPR domain targets the BUB-1-BUB-3 complex to C. elegans kinetochores. Journal of Cell Biology 223: e202402036


Lara-Gonzalez P., Variyar S., Budrewicz J., Schlientz A., Varshney N., Bellaart A., Moghareh S., Nguyen A.C.N., Oegema K., Desai A. (2023) Cyclin B3 is a dominant fast-acting cyclin that drives rapid early embryonic mitoses. Biorxiv

Houston J., Ohta M., Gómez-Cavazos J.S., Deep A., Corbett K.D., Oegema K., Lara-Gonzalez P., Kim T.,  Desai A. (2023) BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses. Current Biology.

Wang L., Heffner C., Vong K.I., Barrows C., Ha Y.J., Lee S., Lara-Gonzalez P., Jhamb I., Van Der Meer D., Loughnan R., Parker N., Sievert D., Mittal S., Issa M.Y., Andreassen O.A., Dale A., Dobyns W.B., Zaki M.S., Murray S.A., Gleeson J.G. (2023)  TMEM161B modulates radial glial scaffolding in neocortical development. Proceedings of the National Academy of Sciences 120: e2209983120

See also: Decoding the Development of the Neocortex

Rocha H., Simões P.A., Budrewicz J., Lara-Gonzalez P., Carvalho A.X., Dumont J., Desai A., Gassmann R. (2023). Nuclear-enriched protein phosphatase 4 ensures outer kinetochore assembly prior to nuclear dissolution. Journal of Cell Biology 222: e202208154.


Ferguson C.J., Urso O., Bodrug T., Gassaway B.M., Watson E.R., Prabu J.R., Lara-Gonzalez P., Martinez-Chacin R.C., Wu D.Y., Brigatti K.W., Puffenberger E.G., Taylor C.M., Haas-Givler B., Jinks R.N., Strauss K.A., Desai A., Gabel H.W., Gygi S.P., Schulman B.A., Brown N.G., Bonni A. (2022) APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain. Molecular Cell 82: 90-105


Lara-Gonzalez P (#), Kim T, Oegema K, Corbett K, Desai A (#). (2021) A tripartite mechanism catalyzes Mad2-Cdc20 assembly at unattached kinetochores. Science 371: 64-67.
(#) Co-corresponding authors

Lara-Gonzalez P. (#), Pines J. (#), Desai A (#). (2021) Spindle assembly checkpoint activation and silencing at kinetochores. Seminars in Cell and Developmental Biology 117: 86-98 (Review)
(#) Co-corresponding authors

de Groot C., Houston J., Davis B., Gerson-Gurwitz A., Monen J., Lara-Gonzalez P., Oegema K., Shiau A.K., Desai A. (2021) The N-terminal Tail of C. elegans CENP-A Interacts with KNL-2 and is Essential for Centromeric Chromatin Assembly. Molecular Biology of the Cell 32: 1193-1201

Kawashima A.T., Wong C., Lorden G., King C.C., Lara-Gonzalez P., Desai A., Gingras A.-C., Newton A.C. (2021) The PHLPP1 N-Terminal Extension is a Mitotic Cdk1 Substrate and Controls an Interactome Switch. Molecular and Cellular Biology 41, e00333-20


Houston J., Lara-Gonzalez P., Desai A. (2020) Rashomon at the kinetochore: Function(s) of the Mad1-cyclin B1 complex. Journal of Cell Biology 219: e202006006. (Review).

What is the Rashomon effect?

Bel Borja L., Soubigou F., Taylor S.J., Fraguas Bringas C., Budrewicz J., Lara-Gonzalez P., Sorensen Turpin C.G., Bembenek J.N., Cheerambathur D.K., Pelisch F. (2020) BUB-1 targets PP2A:B56 to regulates chromosome congression during meiosis I in C. elegans oocytes. eLife 9, e65307

Gomez-Cavazos J.S., Lee K.Y., Lara-Gonzalez P., Li Y., Desai A., Shiau, A.K., Oegema K. (2020) A non-canonical BRCT-phosphopeptide recognition mechanism underlies RhoA activation in cytokinesis. Current Biology 30: 3101-315


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Lara-Gonzalez P. (#), Moyle M.W., Budrewicz J., Mendoza-Lopez J., Oegema K., Desai A (#). (2019). The G2-to-M Transition Is Ensured by a Dual Mechanism that Protects Cyclin B from Degradation by Cdc20-Activated APC/C. Developmental Cell 51: 313-325
(#) Co-corresponding authors

Chen A.L., Lum K.M., Lara-Gonzalez P., Ogasawara D., Cognetta A.B. 3rd., To A., Parsons W.H., Simon G.M., Desai A., Petrascheck M., Bar-Peled L., Cravatt B. (2019) Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. Nature Chemical Biology 15: 453-462


Hattersley N. (*), Lara-Gonzalez P. (*), Cheerambathur D., Gomez-Cavazos J.S., Kim T., Prevo B., Khaliullin R., Lee K.Y., Ohta M., Green R., Oegema K., Desai A. (2018). Employing the one-cell C. elegans embryo to study cell division processes. Methods in Cell Biology 144: 185-231.
(*) Co-first authors

Oegema K., Davis R.L., Lara-Gonzalez P., Desai A., Shiau A.K. (2018) CFI-400945 is not a selective cellular PLK4 inhibitor. Proceeding of the Natural Academy of Sciences USA 115: E10808-E10809


Kim T. (*), Lara-Gonzalez P. (*), Prevo B., Meitinger F., Cheerambathur D.K., Oegema K., Desai A. (2017). Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates. Genes and Development 31: 1089-1094.
(*) Co-first authors
Cover article

Lara-Gonzalez P, Kim T, Desai A. (2017). Taming the Beast: Control of APC/CCdc20-Dependent Destruction. Cold Spring Harb Symposia on Quantitative Biology 82: 111-121. (Review)

Wang S., Tang N.H., Lara-Gonzalez P., Zhao Z., Prevo B., Cheerambathur D.K., Chisholm A.D., Desai A., Oegema K. (2017) A toolkit for GFP-mediated tissue-specific protein degradation in C. elegans. Development 144 (14): 2694-2701


Espeut J., Lara-Gonzalez P., Sassine M., Shiau A.K., Desai A., Abrieu A. (2015) Natural loss of Mps1 kinase in nematodes uncovers a role for Polo-like kinase 1 in spindle checkpoint initiation. Cell Reports 12, 58-65

Kim T., Moyle M.W., Lara-Gonzalez P., De Groot C., Oegema K., Desai A. (2015) Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans. Journal of Cell Biology 209, 507-517


Lara-Gonzalez P. (*), Westhorpe F.G. (*), Taylor SS. (2012). The spindle assembly checkpoint.  Current Biology 22: R966-80. (Review)
(*) Co-first authors


Lara-Gonzalez P., Scott M.I., Diez M., Sen O., Taylor S.S. (2011). BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner. Journal of Cell Science 124: 4332-45.

Westhorpe F.G., Tighe A., Lara-Gonzalez P., Taylor S.S. (2011). p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit. Journal of Cell Science 124, 3905-16

Romo, X., Pastén, P., Martínez, S., Soto, X., Lara, P., de Arellano, A.R., Torrejón, M., Montecino, M., Hinrichs, M.V. and Olate, J. (2008). xRic-8 is a GEF for Gsalpha and participates in maintaining meiotic arrest in Xenopus laevis oocytes. Journal of Cell Physiology 214, 673-80

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